Chronic obstructive pulmonary disease, biliary cirrhosis, cholangitis, and osteoarthritis exhibit overlapping detrimental SASP profiles, characterized by the presence of interleukin-6 (IL-6), interleukin-8 (IL-8), and matrix metalloproteinase (MMP). The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.