RET and lung cancer: Among the 35 ALK fusion-negative lung cancer samples, EricScript and Lumpy reported (by default without filtering) 39 and 46 unknown-significance fusions, respectively, whereas STAR-Fusion reported five such fusions involving the tumor suppressor gene CDKN2A, and SplitFusion reported two NCOA4::RET cases with the NCOA4 fusion junction aligned on the exon boundary (Figures 3 and S3).