Interestingly, SplitFusion detected novel fusions that have not been reported previously in lung cancer, including one squamous cell carcinoma with FGFR3::JAKMP1 fusion, one adenocarcinoma with CLIP2::BRAF fusions (two fusion isoforms in one tumor), and one adenocarcinoma with ITPR2::ETV6 fusion (Figures 4A and S7). Here, ITPR2 is linked to adenocarcinoma.