STAT3 and type 1 diabetes mellitus: This overexpression may exacerbate T1DM pathogenesis through several mechanisms: it promotes the survival of autoreactive T‐cells by inhibiting apoptosis‐related genes like PDCD4, enhances inflammatory cytokine production via the STAT3 and NF‐κB pathways, and increases beta‐cell susceptibility to cytokine‐induced apoptosis.