Multiple daily injections regimens of insulin and frequent monitoring of glucose levels are important components of T1D management.4 Although insulin therapy, in comparison with other treatments, leads to a moderately lower all-cause mortality rate, there are still difficulties around T1D treatments, such as weight gain, excessive glucose fluctuations, hypoglycemia, and diabetic ketoacidosis (DKA). This evidence concerns the gene INS and Hypoglycemia.