We found a positive association between the risk of nephropathy in diabetic patients in the highest quartile of thrombotic index compared with patients in the lowest quartile of the crude pattern (OR: 4.66, 95% CI: 2.34–9.29, p trend < 0.001), Model 1 adjusted for age, BMI and energy (OR: 4.14, 95% CI: 2.03–8.44, ptrend < 0.001), and Model 2 adjusted for physical activity, fasting blood glucose, fasting insulin level, lipid profile including cholesterol, TG, LDL, HDL, creatinine level, and CRP (OR: 4.03, 95% CI: 1.86–8.72, ptrend < 0.001). The gene discussed is INS; the disease is kidney disorder.