The reason for this is that monomeric human IgA can cross-link Fc α receptor I (FcαRI) expressed on polymorphonuclear (PMN) leukocytes, such as neutrophils, and induce potent reactive oxygen species production, phagocytosis, neutrophil extracellular trap formation, cytokine release, as well as antibody-dependent cellular cytotoxicity (ADCC) directed against the tumor cells, as reviewed (9, 10). The gene discussed is CD79A; the disease is neoplasm.