High-throughput mutation analysis identified novel somatic mutations affecting p110γ (N66K, D161E, R178L, S348I, K364N, T503M, R542W, E602V, and E740K) and p110δ (V397A) across various tumor types, including breast cancer, LC, ovarian cancer, and prostate cancer (Kan et al., 2010). The gene discussed is PIK3CD; the disease is laryngotracheoesophageal cleft.