Activation of tumor-associated PAM signaling also promotes the expression of VEGF, a key mediator of angiogenesis and a chemokine that attracts immunosuppressive MDSCs and Tregs (Powell et al., 2012; Ostrand-Rosenberg and Fenselau, 2018; Goel and Mercurio, 2013). This evidence concerns the gene VEGFA and neoplasm.