Administering PI3K inhibitors, such as BKM120, in combination with chemotherapeutic agents, such as carboplatin, pemetrexed disodium, cisplatin, and etoposide, may enhance tumor cell killing (NCT01723800, NCT02194049) (Medifind, 2012; University of California, Davis, 2014). The gene discussed is PIK3CA; the disease is neoplasm.