Furthermore, circRNAs have been shown to play significant roles in the initiation and progression of ICNS, [20, 21] such as hsa_circ_0116108 (also named circPKNOX1) affected the progression of intervertebral disc disease by regulating the expression of KIAA0355 via miR-370-3p [22]. This evidence concerns the gene GARRE1 and intervertebral disk degenerative disorder.