An effective AChE inhibitor must either bind to the CAS or PAS region, or possess a linker of suitable length and structure that bridges these two sites, allowing interaction with both, especially have two aromatic residues.7 In addition, it is well-established that AD is associated with the self-assembly of Aβ peptides, a cornerstone of the amyloid cascade hypothesis. Here, ACHE is linked to Alzheimer disease.