The results of the IVW model showed that 15 plasma protein markers may increase the risk of osteoporosis, and there may be a strong causal relationship between serine/threonine-protein kinase PIM-1, potassium-transporting ATPase subunit beta (ATP1B1), ZFP175, chordin-like protein 2, and osteoporosis. This evidence concerns the gene ATP1B1 and osteoporosis.