Heterozygous pathogenic TP63 variants are associated with five different syndromes with overlapping phenotypic features: ectrodactyly, ectodermal dysplasia, cleft lip/palate syndrome (EEC), ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, Rapp–Hodgkin syndrome (RHS), acro-dermo-ungual-lacrimal-tooth (ADULT) syndrome, and limb-mammary syndrome (LMS) also rare TP63 variants are causative for Orofacial Cleft syndrome (OFC8) and non-syndromic split-hand/foot malformation type 4 syndrome (SHFM4) [2]. The gene discussed is TP63; the disease is split hand-foot malformation 4.