The variability in regulatory prediction of TP53 across cancers was unsurprising, as TP53 has multiple promoters, isoforms, an antisense-transcriptional regulators in WRAP3, TF-binding sites of environmentally responsive TFs like NFKb, and context-depending miRNA interactions [68], amongst other regulatory mechanisms (Supplementary Fig. S11) [63–67]. The gene discussed is TP53; the disease is cancer.