The least common set of gene-regulator pairs were those that were not predictive in tumour tissues but were predictive in tumour-adjacent tissues (median percent tumour-adjacent specific regulatory predictions: miRNA = 12.07%, TF = 2.38%, lncRNA = 7.94%, DNAm = 7.45%, CNV = 11.68%, SNP = 85.57%). The gene discussed is TF; the disease is neoplasm.