At the same time, it was observed that HGF was significantly reduced to 1,083 pg/ml in patients with heart failure treated by CRT implantation, which was lower than the optimal cutoff value of 1,598 pg/ml for predicting 2-year all-cause mortality in HFpEF patients in our study, which indicates that whether in HFrEF decompensated patients or in HFpEF patients, HGF elevation is an independent predictor of all-cause mortality in two different subgroups of HF. The gene discussed is HGF; the disease is heart failure.