ATP2A2 and Sepsis: In sepsis, microcirculation disorders associated with myocardial ischemia and hypoxia, on the one hand, directly affect the production of ATP, reduce the activity of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2), accompanied by the decrease in phospholamban (PLB) phosphorylation, and lead to impaired function of the sarcoplasmic reticulum in the uptake of free calcium.