CircTLK1 can sponge miR-17-5p, activate the poly(ADP-ribose) polymerase 1 (PARP1)/HMGB1 axis, and aggravate the oxidative damage of mitochondrial genome (mtDNA), resulting in mitochondrial dysfunction and cardiomyocyte apoptosis in sepsis (157). The gene discussed is PARP1; the disease is Sepsis.