CD4 and HIV infectious disease: From this picture provided by Dai et al. (76), it is likely that in the HIV infection context, the overexpression of PSGL-1 in ART-treated individuals may provoke increased formation of platelet-CD4+ T-cell aggregates which are unfavorable to CD4+ T-cell survival, and may potentially induce the development of CVDs as well, when other varieties of plasma cells are taken into consideration.