CAV2 and neoplasm: Additionally, opposing effects of Cav-1 and Cav-2 have been noted in tumor-induced angiogenesis (Capozza et al., 2012; Woodman et al., 2003), suggesting that Cav-2 is not only a partner of Cav-1 in caveolae formation but also assists in fine-tuning basic cellular processes in a counterbalancing manner (de Almeida, 2017).