While Cav-1 plays a role in sepsis by regulating membrane traffic and intracellular signaling pathways (Lannes-Costa et al., 2022), Cav-1 directly modulates ROS production via NADPH oxidase (Michell et al., 2021; Cai et al., 2014), as NADPH oxidase subunits have been shown to localize within Cav-1-containing caveolae across various cell types (Ushio-Fukai, 2006). This evidence concerns the gene FMO5 and Sepsis.