Some scholars also found that some molecular markers related to the pathogenesis of LCPD, including VEGF, eNOS, and IL-6, may be involved in the disease progression of LCPD, potentially helping the treatment and diagnosis to some extent (Spasovski et al., 2023) (as shown in Figure 1). The gene discussed is NOS3; the disease is Legg-Calve-Perthes disease.