TLR7 and cancer: By encapsulating the near-infrared region II (NIR-II) PTA IR1048 and the Toll-like receptor 7 (TLR7) agonist immunological adjuvant R837 within the amphiphilic polymer F127, we have synthesized amphiphilic nanoparticles and coated their surface with cancer cell membranes (4T1) to fabricate biomimetic nanoparticles (cancer cell membrane coated F127/(R837 and IR1048) [CFRI]).