As patients with hs-cTnI elevation in the present study population did not have an overall more pronounced cerebrovascular risk profile and had a comparatively low prevalence of CAD, our findings support the growing evidence that cTn elevation in connection with sICH is primarily related to myocardial damage along the brain-heart axis and less to macrovascular ischemic conditions. Here, TNNI3 is linked to coronary artery disorder.