TNF and colitis: co‐delivered TNF‐α siRNA and IL‐22 (a healing‐promoting cytokine), addressing inflammation and promoting mucosal healing simultaneously.[236] The application of LNPs to deliver IL‐22 mRNA increased IL‐22 protein in the colonic mucosa of mice, promoting the accelerated healing of DSS‐induced colitis.[237] Notably, Arranz et al.