STK11 and experimental autoimmune encephalomyelitis: utilized cationic lipid‐assisted PEG‐PLGA NPs to deliver Lkb1 siRNA to DCs in the draining lymph nodes for controlling the progression of MS in a mouse model (experimental autoimmune encephalomyelitis [EAE]).[273] In vitro experiments demonstrated that NP‐mediated delivery of Lkb1 siRNA could suppress Lkb1 and sustain an immunotolerant phenotype in DCs.