TNF and colitis: administered TNF‐α siRNA to mice with dextran sulfate sodium (DSS)‐induced colitis using modified CD.[234] CD‐TNF‐α siRNA treatment effectively silenced TNF‐α mRNA (73 ± 13%) and IL‐6 (58 ± 19%) mRNA in proximal colon tissues, and improved the clinical symptoms, including weight gain and reduced rectal bleeding.