Furthermore, the group targeted three upregulated genes in psoriasis (KRT17, DEFB4, and TSLP) for siRNA delivery, leading to reduced specific psoriasis markers (e.g. involucrin, keratin 16, and Ki‐67) and inhibiting keratinocyte proliferation in a full‐thickness bovine psoriasis‐reconstructed skin model.[257]. This evidence concerns the gene KRT17 and psoriasis.