detected significantly elevated levels of TNF‐α, interferon gamma‐induced protein 10 (IP‐10), and keratinocyte‐derived cytokine (KC) proteins in colonic tissues of colitis mice.[239] The researchers then targeted these three inflammatory mediators and designed calcium phosphate (CaP)/PLGA NPs carrying siRNAs against them.[239] Through efficient delivery to intestinal epithelial cells (IECs) and immune cells in DSS‐induced colitis mice, triple siRNA CaP/PLGA NPs suppressed TNF‐α mRNA by 40%, which led to KC and IP‐10 mRNA decreasing by 50% and reduced disease activity scores. Here, CALCA is linked to colitis.