Macrophages also significantly contribute to this condition by secreting a variety of inflammatory mediators, including TNF‐α, IL‐1β, and IL‐6, orchestrating a critical role in the cytokine network that drives synovial inflammation.[170] Furthermore, macrophages exhibit the ability to facilitate endothelial cell chemotaxis and proliferation, promoting angiogenesis and the infiltration of inflammatory cells.[171] Therefore, modulating macrophages via nucleic acid delivery is a promising avenue for RA treatment as it can reduce the inflammatory response and hinder disease progression. This evidence concerns the gene TNF and rheumatoid arthritis.