TNF and colitis: devised lipid‐based NPs, known as β7I‐tsNPs, for the precise delivery of CyD1 siRNA to colonic mononuclear cells, effectively normalizing CyD1 mRNA levels and concomitantly suppressing TNF‐α and IL‐12.[246] These NPs substantially ameliorated colonic tissue damage in colitis mice, proficiently curbing white blood cell infiltration and eliciting a reversal of both weight loss and reduced blood cell hematocrit levels.