TLR7 and arthritic joint disease: investigated the therapeutic effects of lentivirally delivered TLR7 shRNA (Lt.shTLR7) in CIA rats.[209] The intraarticular injection of Lt.shTLR7 effectively suppressed TLR7 in FLSs and reduced vascular endothelial growth factor (VEGF) and pro‐inflammatory cytokines, resulting in decreased microvessel density (approximately 60% of the control group) and the inhibition of arthritis.