GPX4 and colorectal carcinoma: A variety of cellular metabolic pathways and antioxidant systems protect CRC cells from ferroptosis,[9] and wherein GPX4 employing glutathione (GSH) as the substrate plays the central role in avoiding lipid peroxidation and evading ferroptotic cell death.[10] GSH depletion using intracellular Fenton reaction or GSH synthesis inhibition using l‐buthionine sulfoximine (BSO) are preferable tactics for GPX4 inhibition.[11] Herein, we construct a photothermal nanoplatform supplied with GPX4 inhibitors to mediate the cascade loop of ferroptosis induction and immunotherapy of CRC.