GPX4 and neoplasm: Antigen‐shielded BOFG with the diameter less than 75 nm could preferentially accumulate at the tumor site depending on the advantage of the enhanced permeability and retention (EPR) effect.[13] The photothermal effect under NIR irradiation, the Fenton reaction catalyzed by Fe3+‐GA MPNs to generate hydroxyl radical and the BSO‐blocked GSH synthesis inactivating GPX4 collectively facilitate BOFG to induce ICD of CRC.