Nevertheless, only recently a highly effective triple combination drug comprising two correctors—tezacaftor (VX-661) and elexacaftor (VX-445), to rescue p.Phe508del-CFTR PM traffic—with a potentiator—ivacaftor (VX-770), to rescue the gating defect—was shown to be efficacious in CF individuals bearing one or two p.Phe508del alleles.10 The gene discussed is CFTR; the disease is cystic fibrosis.