Given that neither Atp2b4-p.P895S nor Prr35-p.P186L mice displayed a myopic phenotype, and the reduced CRC observed in Lama5-p.R1565C mice did not coincide with the continuous axial elongation seen in humans with high myopia and MM, we focused our investigations on discerning the mechanisms underlying the myopic phenotype observed in Nfe2l3-p.K580T mice. The gene discussed is LAMA5; the disease is colorectal carcinoma.