There were no significant differences in axial components between the two groups (Fig. S5d–g) but the CRC of Lama5-p.R1565C mice was significantly smaller than that of WT mice at P70 (1.517 ± 0.022 versus 1.483 ± 0.011 mm; P = 0.007; Fig. 1j). This evidence concerns the gene LAMA5 and colorectal carcinoma.