To identify new ESCC driver genes, we have collected 508 pairs of ESCC tissues and adjacent esophageal tissues and conducted whole genome sequencing (WGS) in our previous study and found a set of new significant mutation genes related to ESCC, including YEATS domain containing 2 (YEATS2) (Cui et al., 2020). This evidence concerns the gene YEATS2 and esophageal squamous cell carcinoma.