As a signal transducer, IL6ST could regulate multiple tumors development processes including head and neck squamous cell carcinoma (Sriuranpong et al., 2003), bladder cancer (He et al., 2021), hepatocellular carcinoma (Desideri et al., 2023), gastric cancer (Chen et al., 2020), colorectal cancer (Zhao et al., 2024), breast cancer (Wang et al., 2020), prostate cancer (Sternberg et al., 2024). This evidence concerns the gene IL6ST and gastric cancer.