Besides, another study suggested that roxadustat had little effect on renal fibrosis even though a high dose of roxadustat transiently (7 days) potentiated gene expression of profibrogenic molecules, including plasminogen activator inhibitor 1 (Pai-1) and connective tissue growth factor (Ctgf) in the UUO model (Kabei et al., 2020). Here, CCN2 is linked to renal fibrosis.