Notably, a heterozygous pathogenic PALB2 variant has been documented in cases of acute lymphoblastic leukemia in a 6-year-old patient diagnosed with acute lymphoblastic leukemia and secondary Ewing sarcoma at the age of 12 years, originating from a family with a notable history of cancer across both paternal and maternal lineages. The gene discussed is PALB2; the disease is Ewing sarcoma.