Adipocytes have adverse regulatory effects in the bone marrow microenvironment, as they can surround tumor tissue to evade destruction and secrete metabolic regulators that affect the energy metabolism and insulin sensitivity of surrounding cells, thereby modulating the bone marrow microenvironment, inhibiting normal hematopoietic stem cell function, and promoting leukemia cell proliferation and differentiation (33, 34). The gene discussed is INS; the disease is neoplasm.