APS is a heterogeneous autoimmune disorder characterized by arterial, venous, or small vessel thrombosis and pregnancy morbidity, all associated with the presence of autoantibodies, including aCL (anti-cardiolipin antibodies), anti-β2GPI (anti-beta2-glycoprotein I), and LAC (lupus anticoagulant). Here, APOH is linked to autoimmune polyendocrinopathy.