Patients diagnosed with CVID have reduced number of iNKT cells compared to healthy individuals, in which their phenotype was predominantly CD4+, with a higher and lower number of IFN-γ and IL-17-producing cells, respectively, compared to control after PBMC stimulation with α-GalCer (238), although other reports show otherwise (239). The gene discussed is CD4; the disease is common variable immunodeficiency.