From a clinical perspective, patients with DOCK8 deficiency have symptoms resembling those of AD-HIES, such as recurrent sinopulmonary infections, mucocutaneous Candidiasis, Staphylococcal skin abscesses, heightened IgE levels, eczema, eosinophilia, and an increased likelihood of developing malignancies (154). Here, DOCK8 is linked to Alzheimer disease.