CD8A and Herpesviridae infectious disease: STAT3-deficient patients have been shown to exhibit a diminished capacity of CD8+T cells to manage herpesvirus infections (37), which may be explained by the observation that in STAT3 deficient patients, there are increased levels of naïve CD8 T cells, and a concomitant decrease in central memory, effector memory, and terminally differentiated effector memory cytotoxic CD8 T cells (19).