From a clinical perspective, patients with DOCK8 deficiency have symptoms resembling those of AD-HIES, such as recurrent sinopulmonary infections, mucocutaneous Candidiasis, Staphylococcal skin abscesses, heightened IgE levels, eczema, eosinophilia, and an increased likelihood of developing malignancies (154). This evidence concerns the gene DOCK8 and hyperinsulinemic hypoglycemia, familial, 4.