Atopic conditions, such as food allergies, are a significant feature of hyper-IgE syndromes (HIES), with their presentation varying based on the underlying genetic mutation.Patients with DOCK8, STAT3, or atopic dermatitis exhibit distinct sensitization patterns (209), with allergic symptoms and skin prick test outcomes strongly aligning with specific IgE levels in DOCK8 and atopic dermatitis cases, aiding dietary management decisions (210). This evidence concerns the gene STAT3 and atopic eczema.