A case has been reported of a family with STAT6 GOF disease presenting with severe early-onset atopy and follicular lymphoma and Linked to a newly identified germline heterozygous STAT6 mutation, c.1255G>C p.D419H, residing in the DNA binding domain of STAT6 and co-segregating with the clinical phenotype (138). The gene discussed is STAT6; the disease is follicular lymphoma.