A global study of 136 DOCK8 cases revealed that more than 70% experienced allergy-related symptoms, including food-induced anaphylaxis in 16%, as well as drug allergies, asthma, and rhinitis (163) Food allergies in DOCK8-HIES patients can persist even after HSCT, despite achieving full donor chimerism (211) PGM3-HIES patients often have multiple allergies (168), whilst WAS patients and murine models frequently develop IgE-mediated reactions to environmental and food allergens (212). This evidence concerns the gene IGHE and allergic disease.