However, in the present study, the CD352 expression level was significantly higher in PBMCs from tumor patients than in peripheral blood PBMCs from healthy volunteers, but decreased with proximity to the TME tissues; this was accompanied by high expression of immunosuppressive molecules such as CD39, TIM3, and PD1 and a decrease in effector killer cytokines. This evidence concerns the gene HAVCR2 and neoplasm.