Therefore, we believe that CD352 expressed on CD8+T cells in NSCLC can be used as a marker of initial exhaustion, and most of the CD8+T cells in the peripheral blood of tumor patients are in the state of initial exhaustion, whereas PD-1+TIM3+CD8+T cells within the tumor microenvironment are in the state of terminal exhaustion with increased immunosuppressive molecules and severe dysfunction of killing function. Here, HAVCR2 is linked to neoplasm.