Our previous studies had found that IL-8 was also highly expressed in the tumor microenvironment, and high levels of IL-8 were significantly associated with poor prognosis in advanced NSCLC patients treated with HFRT (hypofractionated radiotherapy) PD1 blockade, and that high circulating IL-8 in NSCLC increased apoptosis of effector memory T cells and CD8+T cells (42). This evidence concerns the gene CD8A and neoplasm.