Interestingly, the frequency of CD352+CD8+ T cells showed a distinct trend: the expression frequency of CD352+CD8+ T cells in tumor tissues was significantly lower than that in the paraneoplastic tissues (P < 0.01), whereas the frequency of CD352+CD8+ T cells in the peripheral blood was the highest as compared to that in tumor tissues and peri-tumor tissues (P < 0.001). This evidence concerns the gene SLAMF6 and neoplasm.