A comparison of changes in cytokine levels in plasma and tissue homogenization supernatants from different lung cancer patients revealed that the IL-6, IL-7, IL-10, and IL-17A expression levels were particularly elevated in tumor tissues and were the lowest in plasma supernatants (Figures 3A-D); this finding indicated that the closer the TME, the more pronounced is the inflammatory response. This evidence concerns the gene IL6 and lung cancer.