RING-type E3 ubiquitin ligase RNF146 is a key regulator of the Wnt/β-catenin signaling pathway, which is frequently hyperactivated in HCC SUMOylation of RNF146 leads to activation of Wnt/β-Catenin pathway to promote HCC progression (46). Here, RNF146 is linked to hepatocellular carcinoma.