In contrast, the expression of secreted APRIL and the positive rate of secreted APRIL in lacrimal gland lesions showed a positive correlation with serum IgG4 levels (95% CI: 0.07 to 0.85, r = 0.5820, P = 0.029; 95% CI: 0.14 to 0.87, r = 0.6261, P = 0.017; respectively) (Figures 7C, D). The gene discussed is TNFSF13; the disease is lachrymal gland lesion.