found that MUC1, a mucin overexpressed in pancreatic cancer, regulates polyamine catabolism by stabilizing HIF-1α expression, enhancing its occupancy of the SAT1 promoter, and activating SAT1 gene expression, thereby promoting polyamine metabolism and the production of N1-N-acetylspermine and N8-N-acetylspermine (31). This evidence concerns the gene SAT1 and familial pancreatic carcinoma.