Current research indicates that radiotherapy primarily exerts its immunoadjuvant effects through three mechanisms: Firstly, radiotherapy can induce the release of tumor cell DNA, activating the STING pathway, which promotes the expression of type I interferon, leading to the activation of CD8+ T cells and a cytotoxic T lymphocyte antitumor response (6, 9). The gene discussed is CD8A; the disease is neoplasm.