The results showed that, compared to the 0 Gy group, co-culture with 2 Gy or 10 Gy irradiated NPC cells for 72 hours led to a significant decrease in the expression of CD80, CD86, CD11c, CD40, HLA-DR, CCR5, CCR7, CD205, CD1a, and CD83 on DCs (P<0.01). The gene discussed is CD83; the disease is nasopharyngeal carcinoma.