Consistent with the above‐described observations regarding catabolic factor expression in mouse OA models in vivo (Figure 3D,E), SASP factors were further increased in Col2a1‐Zmiz1 Tg mice (Figure S12A, Supporting Information), but this was reduced by Ad‐Zmiz1 shRNA infection‐mediated knockdown of Zmiz1 in both young and old mice (Figure S12B,C, Supporting Information). The gene discussed is ZMIZ1; the disease is infection.