PTGS2 and infection: OA cartilage was reported to exhibit increased collagenase activity and PGE2 production, which could lead to the degradation of various ECM components through the expression of MMP3 and COX2.[35] Here, we found that Ad‐Zmiz1 infection at the indicated MOI led to increases in collagenase activity and PGE2 production (Figure 2I).