The OA‐related genes up‐regulated by Ad‐Zmiz1 infection included those encoding MMP3 and COX2, which function as main factors of cartilage destruction and inflammation, respectively.[31, 34] Our results showed that Ad‐Zmiz1 infection increased the expression levels of the OA catabolic factors, MMP3 and COX2, at the transcript and protein levels in chondrocytes, and that ZMIZ1 overexpression did not trigger apparent cytotoxicity (Figure 2H; Figure S8F,G, Supporting Information). Here, PTGS2 is linked to infection.