Given that chondrocyte dedifferentiation, which is marked by the loss of anabolic factor expression, leads to chondrocyte senescence,[17] we also assessed the mRNA expression levels of the major anabolic factors, Col2a1, Acan, and Sox9, and found that they were decreased by Ad‐Zmiz1 infection (Figure S6, Supporting Information). This evidence concerns the gene SOX9 and infection.