S100A8 and psoriasis: Simultaneously, reanalysis of scRNA‐seq data from psoriatic mouse skin showed that topical application of BMS‐986165 reduced NGFR expression in the Supraspinous KC subtype, accompanied by reductions in inflammatory genes such as S100a8, S100a9, Il1b and Cxcl3 (Figure 6E), suggesting that TYK2 inhibitor mitigates psoriasis‐like inflammation by modulating NGFR transcription and regulating the inflammatory response in KCs.