Bulk RNA‐seq of skin tissues revealed expression of several psoriasis‐related genes were substantially decreased in the BMS‐986165‐treated group, including proinflammatory cytokines (Il17a, Il17f, Il19, Il1b), chemokines (Cxcl2, Cxcl3, Ccl3, Ccl4), antimicrobial peptides (S100a8, S100a9, Defb14) and keratins (Krt6a, Krt6b, Krt16; Figures 1G and S1D).7, 10, 16. This evidence concerns the gene IL1B and psoriasis.