Notably, 6 clusters related to cell cycle and DNA repair were prominent in pLN+ OSCC, comprising (1) Gap filling DNA repair synthesis and ligation in GG‐NER; (2) homologous DNA pairing and strand exchange; (3) G0 and early G1; (4) cyclin A/B1/B2 associated events during G2/M transition; (5) E2F‐mediated regulation of DNA replication; and (6) aberrant regulation of mitotic exit in cancer due to Rb1 defects. This evidence concerns the gene RB1 and cancer.