Other upregulated genes included TGFβI, that acts as a downstream regulator of the TGF‐β signalling pathway, influencing epithelial–mesenchymal transition (EMT) and contributing to an immunosuppressive microenvironment in various cancers, including cholangiocarcinoma and ovarian cancer; and AURKA, which is a key regulator of the cell cycle.64, 65, 66, 67. The gene discussed is TGFB1; the disease is cancer.