NLRP3 and Parkinson disease: To further investigate the therapeutic potential of targeting NLRP3 phosphorylation at Serine 658 in PD, Nlrp3 KO mice were injected with adeno-associated viruses (AAV) carrying either WT NLRP3 (AAV-WT-NLRP3) or the S658A mutant NLRP3 (AAV-Mut-NLRP3_S658A).