In cancers where TLS are associated with host protection, TLS can be induced locally by injecting relevant chemokines (CCL21, CCL19, and CXCL13), thus eliminating the need for therapeutic immunization against unknown antigens.TLS have emerged as significant components in the tumor microenvironment, playing a crucial role in the immune response against cancer. The gene discussed is CXCL13; the disease is neoplasm.