HAVCR2 and neoplasm: (2) Increased expression of ICIs: For example, increased expression of LAG-3 (lymphocyte activation gene 3 (LAG-3, CD223), T cell immunoglobulin 3 (TIM-3, CD366), and T cell immunoglobulin and ITIM structural domain proteins (TIGIT) in tumor cells or immune cells causes enhanced immunosuppressive signaling, which can weaken the efficacy of ICBs.