Xu et al. demonstrated that stimulation of the cGAMP-STING-IRF3 pathway can induce TREM2 expression, which promotes the phagocytosis of Aβ by microglia, and reduces Aβ deposition and neuronal loss, simultaneously attenuating the pathological morphology and cognitive deficits in AD. The gene discussed is IRF3; the disease is Alzheimer disease.