Further studies demonstrated that cGAS gene deletion in 5xFAD mice alleviated cognitive impairment, Aβ aggregation, neuroinflammation, and cholinergic neuron damage; STING inhibitors also sustainably ameliorated AD pathogenesis, which may be partially attributable to the inhibition of neurotoxic A1 astrocytes [117, 145, 167]. This evidence concerns the gene CGAS and Alzheimer disease.