In line with the MDMi data, the PLCγ2-P522R variant slightly reduced inflammatory cytokine levels in the temporo-occipital cortex and hippocampus of APP/PS1 mice and led to suppression of inflammatory and interferon signaling pathways in CD11b+ microglia isolated from 13-month-old mice without AD-associated stress. The gene discussed is ITGAM; the disease is Alzheimer disease.