While these studies emphasize the importance of TREM2-PLCγ2-driven microglia in mitigating AD-related pathologies and highlight PLCγ2 as a plausible disease-modifying therapeutic target in AD, more data gathered from different models are needed to comprehensively understand the role of PLCγ2-P522R in AD. The gene discussed is TREM2; the disease is Alzheimer disease.