PLCG2 and Alzheimer disease: In contrast, another study revealed no differences in the β-amyloid plaque load or microglial internalization of β-amyloid in 5XFAD mice transplanted with human PLCγ2-P522R iMGLs [16], highlighting the importance of additional studies in different models to comprehensively characterize the role of the PLCγ2-P522R variant in the cellular processes relevant for AD.