Recent research has identified at least two major subtypes of CAFs based on their molecular signatures: the myofibroblastic CAFs (myCAFs), which are involved in ECM remodeling and tissue stiffness, and the inflammatory CAFs (iCAFs), which produce pro-inflammatory cytokines such as IL-6 and IL-8, contributing to immune modulation and tumor progression [29–31]. This evidence concerns the gene IL6 and neoplasm.