This is primarily achieved through the secretion of various bioactive factors, including transforming growth factor-beta (TGF-β), interleukins (IL-2, IL-6), C-X-C motif chemokine ligands (CXCL2, CXCL5, CXCL12, CXCL16), fibroblast growth factor 7 (FGF7), and hypoxia-inducible factor (HIF1A/HIF-1α) [3].For example, TGF-β induces CAF activation, thereby promoting tumor fibroplasia and facilitating tumor progression through its autocrine and paracrine effects. Here, HIF1A is linked to neoplasm.