These exosomes contain specific miRNAs, such as miR-20a-5p and miR-421, which promote IL-6 production and pancrea1ic cancer progression, respectively, by regulating the SIRT3/H3K9ac/HIF-1α axis [37, 49].The cargo of CAF-derived exosomes is crucial for their effectiveness in cancer progression. This evidence concerns the gene HIF1A and cancer.