FAP and neoplasm: For example, Das et al. designed chimeric antigen receptor (CAR) T cells targeting fibroblast activation protein (FAP) through the transcription activator-like effector nuclease (TALEN) gene editing platform, which can effectively deplete cancer-associated fibroblasts CAFs in the tumor microenvironment TME and reduce the physical barriers of the stroma, thereby facilitating the infiltration of T cells [225].