With the purpose to evaluate the specific contribution of IGF1R and IR in mediating ACC cell proliferation, we performed in vitro experiments with four different cell lines: H295R and JIL-2266, derived from ACC primary tumours, and MUC-1 and TVBF-7 derived from ACC metastatic tissues [18–20]. This evidence concerns the gene IGF1R and adrenal cortex carcinoma.