Linsitinib incubation was able to inhibit cell proliferation of all ACC cell lines in basal condition (-42.22 (18.47)%, p < 0.001 vs. control cells in H295R; -21.56 (29.23)%, p < 0.05 vs. control cells in JIL-2266; -36.97 (18.16)%, p < 0.001 vs. control cells in MUC-1; -53.5 (14.6)%, p < 0.001 vs. control cells in TVBF-7) (Fig. 4A-D). This evidence concerns the gene MUC1 and adrenal cortex carcinoma.