Specifically, we aim to investigate: (1) the IGF1R and IR expression and intracellular localisation in ACC and ACA; (2) the IR isoforms expression in ACC, ACA, and NAG and (3) IGF1R and IR involvement in mediating IGF2 tumourigenic effects in four different ACC cell lines and in primary cultured cells derived from surgically removed ACC and ACA. The gene discussed is IGF2; the disease is adrenal cortex carcinoma.