CDC73 and pachyonychia congenita: Ruizhe Zhu et al., through a systematic review and meta-analysis based on individual patient data, found that negative parafibromin immunohistochemical staining is an independent risk factor for recurrence/metastasis (HR 2.73, p = 0.002) and death (HR 2.54, p = 0.004) in patients with PC, while CDC73 gene mutations were not significantly correlated with any clinical outcomes [18].