The univariate logistic regression analysis revealed that FOLR1 levels, albumin–bilirubin (ALBI) scores, the FIB-4 index, alpha-fetoprotein (AFP), alanine aminotransferase (ALT), g-GTP, alkaline phosphatase (ALP), and albumin levels, the platelet count, age, and sex were associated with the occurrence of HCC among CHC patients (Table 2). The gene discussed is AFP; the disease is hepatocellular carcinoma.