Interestingly, our study revealed that high FOLR1 expression was associated with a variety of oncogenic pathways, including the p53, Myc, E2F, and PI3K/AKT/mTOR pathways.These reports might expect any functional role of FOLR1 in tumor aggressiveness/stemness in HCC. The gene discussed is AKT1; the disease is hepatocellular carcinoma.