We found that folate receptor 1 (FOLR1), a known secretory protein [23], was upregulated in tumor tissues and positively associated with 3 major stem/progenitor markers, KRT19, EPCAM, and PROM1 [19, 24, 25], and a poor prognosis for HCC patients in both the discovery and validation cohorts. The gene discussed is PROM1; the disease is hepatocellular carcinoma.