PIK3CA and acute lymphoblastic leukemia: Enrichment analyses carried out on differentially expressed metabolic genes in PI3K-altered T-ALL versus wild-type cases revealed that upregulated genes were mapped to the TCA cycle, the oxidative phosphorylation and the electron transport chain, and the fatty acid metabolism, three major metabolic pathways strongly wired to glycolysis and its derivates (Fig. 2C), along with mTORC1 signaling.