Surprisingly, while in the colon cancer cell line (SW620-KRAB) the inhibition of STAT3 mimicked the effect of NIF treatment with a significant reduction of the ALDHbr cells proportion and tumorsphere-forming efficiency (Supplementary Fig. 1F, G), no effect was observed on the breast CSC population following STAT3 invalidation (Supplementary Fig. 1H, I). Here, STAT3 is linked to colonic neoplasm.