More importantly, CTSB-triggered self-assembly greatly extended the retention time, amplifying photoacoustic imaging signals for sensitive CTSB detection, and enhanced sonodynamic therapy activity for oxygen generation, eliciting a specific CTSB-responsive ultrasound therapy.127 As representatives, these PDCs showcase the versatility of PDC research in addressing specific molecular markers and paving the way for novel therapeutic interventions across various cancer types. Here, CTSB is linked to cancer.