Results showed that the insulin distributed to the liver in animals and dose-dependently reduced blood glucose without hypoglycemia or weight gain and adverse effects in mice, rats and non-human primates.732 Additionally, some physical devices like microneedles, patches and iontophoresis/ultrasound have also been investigated for oral delivery of peptides, piercing or stimulating the oral cavity or intestine to increase local absorption. The gene discussed is INS; the disease is Hypoglycemia.