MAPT and Alzheimer disease: When innate immune cells are activated, programmed cell death can be induced through a variety of pathways, and cell death usually leads to the release of pro-inflammatory cytokines that propagate the innate immune response and can eliminate beta plaques and aggregated Tau proteins.514 However, chronic neuroinflammation caused by cell death is associated with neurodegenerative diseases and may worsen Alzheimer’s disease.