Amyloid plaques mainly contain amyloid β40/42 peptides, which further accumulate leading to neuroinflammation and mishandling of Tau protein.498,499 Based on this, a large number of domestic and international researchers have tried to develop drugs that can remove these two toxic proteins from the brain in the hope of treating AD or slowing down the process.500 Among them, Aβ is produced by hydrolyzing and processing amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase, which means that inhibition of β- and γ-secretase cleavage can inhibit the production of Aβ protein. Here, MAPT is linked to Alzheimer disease.