GLP1R and type 2 diabetes mellitus: Studies have shown that GLP-1 RAs is not only effective in glycemic control, but also beneficial in the prevention of cardiovascular disease and weight loss similar to sodium-glucose transporter 2 (SGLT2) inhibitors.346 For example, liraglutide, dulaglutide and semaglutide can significantly reduce the incidence of major cardiovascular events (MACE) in patients with T2DM.