It has also been shown that Aβ can initiate a deleterious cascade of responses involving Tau pathology and neurodegeneration, i.e., Tau proteins are mediators of Aβ cytotoxicity.510 Possible synergistic effects of Aβ and Tau proteins on microglia and astrocytes, whose interactions mediate cognitive dysfunction in AD patients. Here, MAPT is linked to Alzheimer disease.