GLP1R and type 2 diabetes mellitus: Efpeglenatide, currently in development, is a long-acting GLP-1 RA for controlling blood glucose levels in patients with T2DM.273 Efpeglenatide consists of a modified exendin molecule and is coupled to a fragment of human immunoglobulin 4 by a special technology called long-acting peptide This special coupling technology allows for a more flexible dosing frequency of efpeglenatide.