Nowadays, there are many drugs to promote bone formation, including monoclonal antibodies to sclerostin and recombinant human parathyroid hormone drugs, parathyroid hormone-related protein (PTHrP) analogs, such as Evenity® (romosozumab), Forteo® (teriparatide) and Tymlos® (abaloparatide).548–551 Evenity® has the potentialside effect of increasing the risk of heart attack, stroke or death due to cardiovascular disease. This evidence concerns the gene PTHLH and stroke disorder.