PDC and pancreatic ductal adenocarcinoma: Furthermore, αvβ6 integrin-targeting PDCs, specific to pancreatic ductal adenocarcinomas, hold promise in treating pancreatic ductal adenocarcinomas (PDAC).102 Taken SG3299 as an example, formed by conjugated the DNA-binding pyrrolobenzodiazepine (PBD) payload SG3249 (tesirine) was to an αvβ6-specific 20mer peptide from foot-and-mouth disease virus (FMDV) VP1 capsid protein, this αvβ6-targeted PDC SG3299 demonstrated significantly greater toxicity (up to 78-fold) against αvβ6-expressing cells compared to the non-targeted PDC SG3511 at equimolar doses.