TP53 and neoplasm: Therefore, antagonizing MDM2 and MDMX to activate and stabilize p53 is an important strategy for anti-tumor drug design.330 The peptide PMI (TSFAEYWNLLSP), which inhibits p53-MDM2 interaction with high solubility and specificity, was synthesized by phage display technology.331,332 However, the side chains of multiple residues of PMI are prone to interact with each other.