Therefore, antagonizing MDM2 and MDMX to activate and stabilize p53 is an important strategy for anti-tumor drug design.330 The peptide PMI (TSFAEYWNLLSP), which inhibits p53-MDM2 interaction with high solubility and specificity, was synthesized by phage display technology.331,332 However, the side chains of multiple residues of PMI are prone to interact with each other. The gene discussed is MDM2; the disease is neoplasm.