Additionally, they can be easily modified and redesigned as needed.159 Delivery systems that have been altered to include homing/targeting peptides have demonstrated impressive outcomes in immunotherapy, radiation, chemotherapy, and photo/photodynamic therapy.84,160–166 Several targeting peptides have been developed to bind to receptors that are highly expressed on the surface of tumor cells, including integrins, HER2, and EGFR. The gene discussed is ERBB2; the disease is neoplasm.