Ackr1 encodes the atypical chemokine receptor 1, also known as Duffy antigen, which regulates the availability and distribution of chemokines due to sequestration, degeneration, or transcytosis.4 Since the expression of Ackr1 by endothelial cells facilitates the transcytosis of monocytes into inflamed tissues and presumably mediates resistance to anti-TNF therapy in IBD patients,5 the close interaction of both, Ackr1-expressing vessels and INFLAREs might enhance inflammatory processes in intestinal diseases. The gene discussed is ACKR1; the disease is inflammatory bowel disease.